Genetic Deficiency of Flavin-Containing Monooxygenase-3 ( Fmo3 ) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels

Diana M. Shih,Weifei Zhu,Rebecca C. Schugar,Yonghong Meng,Xun Jia,Aika Miikeda,Zeneng Wang,Marina Zieger,Richard Lee,Mark J. Graham,Hooman Allayee,Rita M. Cantor,Christian Mueller,J. Mark Brown,Stanley L. Hazen,Aldons J. Lusis

Genetic Deficiency of Flavin-Containing Monooxygenase-3 ( Fmo3 ) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels

2019

Diana M. Shih
Weifei Zhu
Rebecca C. Schugar
Yonghong Meng
Xun Jia
Aika Miikeda
Zeneng Wang
Marina Zieger
Richard Lee
Mark J. Graham
Hooman Allayee
Rita M. Cantor
Christian Mueller
J. Mark Brown
Stanley L. Hazen
Aldons J. Lusis

Objective— FMO (flavin-containing monooxygenase) 3 converts bacterial-derived trimethylamine to trimethylamine N-oxide (TMAO), an independent risk factor for cardiovascular disease. We generated FM...

Keywords:

Biochemistry
Diabetes mellitus
Thrombosis
Biology
Flavin-containing monooxygenase
Monooxygenase
Trimethylamine
Lipid metabolism
plasma lipids
Trimethylamine N-oxide

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