A Convenient and General Approach to the Synthesis of Properly Protected d-Nucleoside-3′-hydrogenphosphonates via Phosphite Intermediates.

J. E. Marugg,M. Tromp,E. Kuyl-Yeheskiely,G. A. van der Marel,J. H. van Boom

A Convenient and General Approach to the Synthesis of Properly Protected d-Nucleoside-3′-hydrogenphosphonates via Phosphite Intermediates.

1986

J. E. Marugg
M. Tromp
E. Kuyl-Yeheskiely
G. A. van der Marel
J. H. van Boom

Aus den Nucleosiden (I) entstehen mit dem Salicyl-chlorphosphit (II) die Substitutionsprodukte (III), die mit Pyridin/ Wasser zu den Phosphonaten (IV) reagieren.

Keywords:

Nucleoside
Nucleic acid
Organic chemistry
Chemistry

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