Синтез, противоопухолевые и антибактериальные свойства производных 3-бензил-спиро[бензо[ h ]-хиназолин-5,1’-циклогептан]-4(6 H )-она

The reaction of ethyl 4’-amino-1H-spiro[cycloheptane-1,2’-naphthalene]-3’-carboxylate with benzylisothiocyanate, followed by cyclization of the intermediate thiourea was developed as a method for the synthesis of 3-benzyl-2-thioxo-2,3-dihydro-1H-spiro[benzo[ h ]quinazoline-5,1’-cycloheptane]-4(6 H )-one. The latter compound in the presence of alkali was alkylated to 2-alkylthiosubstituted 3-benzyl-3H-spiro[benzo[ h ]quinazoline-5,1’-cycloheptane]-4(6 H )-ones. The antitumor activity (against Ehrlich’s ascites carcinoma and sarcoma 180) and antibacterial properties of the synthesized compounds were studied using Gram-positive ( St. aureus 200p and 1) and Gram-negative ( Sh. flexneri 6858 and E. coli 0 – 55) microbes as test objects.