The Effect of Ethanol Leaf Extract of Moringa oleifera on the Lipid Profile of Malaria Infected Mice

The effect of ethanol leaf extract of Moringa oleifera on the lipid profile of malaria induced mice was analysed. The experimental animals were divided into six groups with each group consisting of four mice.Groups 1 (positive control) and 6 (negative control) were treated with 5mg/kg body weight of distilled water, group 5 (standard control) was treated with 5mg/kg body weight of artesunate while groups 2 ,3 and 4 were treated with 45,90 and 180 mg/kg body weight of Moringa oleifera ethanol leaf extract .The result shows that the mean total cholesterol for mice in groups 2,3,4 and 5 were non-significantly (p>0.05) lower than the values for mice in groups 1 (Positive control) and 6 (negative control).There was a non-significant (p>0.05) increase in the high density lipoprotein (HDL) concentration of mice in all the test groups administered graded doses of the extract (45,90 and 180 mg/kg body weight ) when compared to the HDL concentration of mice in the three control groups (positive ,negative and standard). The low density lipoprotein (LDL) concentration of mice in groups 2, 3, 4 and 5 were nonsignificantly (p p>0.05) lower than that for mice in group 1 (positive control) and 6 (negative control). Triacylglycerol (TAG) concentrations of mice in groups 2, 3, and 5 were non-significantly (p>0.05) lower than the value for mice in group 1 (positive control),4 and 6 (negative control).