PP278-SUN: Outstanding abstract: Vitamin D Deficiency Reduces Fasted Muscle Protein Synthesis Rate in Old Rats Through Ectopic Fat Deposition and Increased EIF2α Phosphorylation

Rationale: Critically ill children are at high risk of developing nutritional deficiencies, and hospital undernutrition is known to be a risk factor for morbidity and mortality in children. Clinical guidelines are used to standardize and provide better care in the pediatric intensive care unit (PICU). The study aims were to examine nutrition support practices before and after implementation of nutrition support guidelines in the PICU. Methods: Chart review of dietary intake for first 8 days of PICU admission prior to (Oct-Dec 2012) and after (Oct-Dec 2013) educational interventions and training completed during August 2013 by the nutrition support team to all nursing and clinical staff. IRB approved. Results: 191 patients: age 1.4 (0.3 7.5) yrs (median (25 75th percentile) and PICU length of stay (LOS) 6 (4 10) days; and 193 patients, 1.8 (0.5 8.2) yrs and PICU LOS 6 (4 10) days preand post-implementation, respectively, were included.