Enantiomeric Resolution of Diclofop-methyl by HPLC on Chiralcel OD Column

A chiral stationary phase(CSP) was prepared by coating cellulose tris(3,5dimethylphenyl carbamate)(CDMPC) onto aminopropylated spherical silica gel.A pair of pesticide diclofopmethyl enantiomers were directly resolved on CDMPCCSP by normalphase system.The results indicated that retention and stereoselectivity of diclofopmethyl were dramatically influenced by the kinds and the contents of alcohols in mobile phase.Using isopropanol as alcoholic modifier is very potent in chiral separation of diclofopmethyl.Efficient chiral resolution were obtained by using ternary mobile phases: hexane/2propanol /ethanol.