Simultaneous Blockade of Costimulatory Signals CD28-CD80 and CD40-CD154 Combined with Monoclonal Antibody against CD25 Induced a Stable Chimerism and Tolerance without Graft-versus-Host Disease in Rat

Z.X. Zhu,L.-y Fan,Q. Wang

Simultaneous Blockade of Costimulatory Signals CD28-CD80 and CD40-CD154 Combined with Monoclonal Antibody against CD25 Induced a Stable Chimerism and Tolerance without Graft-versus-Host Disease in Rat

2011

Z.X. Zhu
L.-y Fan
Q. Wang

Background: The conditioning regimen to induce chimerism for immune tolerance is usually accompanied by high toxicity and graft-versus-host disease (GVHD). Our aim was to explore a

Keywords:

Chimera (genetics)
Transplantation Conditioning
Graft-versus-host disease
CD80
Immunology
Blockade
CD154
Medicine
Monoclonal antibody
Immune tolerance
Transplantation
General surgery
Cytotoxic T cell
Antigen
Pharmacology
tolerance induction
IL-2 receptor

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