BILE INFECTION AND ITS IMPACT ON LIVER IN PATIENTS OF GALL STONE DISEASE

Context: Diseases of gallbladder are very common in digestive tract disorders the commonest being cholelithiasis. Gallstone disease not only affects the biliary tree but can also cause bile infection and biliary microorganism is known to cause significant liver injury. Aims: To see the bile infection and its impact on liver in patients of GSD (Cholelithiasis, Chronic cholecystitis, CBD Stones) Methods and Material: All patients being subjected for planned cholecystectomy were taken as subjects irrespective of age, sex and co-morbid conditions. Results: 90 patients were included in study. In 78 out of 90 patients bile culture was sterile and in 12 patients it was infected.Choledocholithiasis was associated with a greater incidence of positive bile cultureand abnormal liver histology. Conclusions: Infected bile leads to more damage to liver and incidence of infected bile and liver histology changes is more in choledocholithiasis.