Clinical significance of HGF and NMP22 of voided urine tests for post-operative bladder cancer

Objective:To evaluate clinical significance of Hepatocyte Growth Factor(HGF) and Nuclear Matrix Protein 22(NMP22) of voided urine tests in detecting the relapse of post-operative bladder cancer.Method:A total of 92 patients(males 79,females 13) with bladder cancer and 31 healthy volunteers enrolled in this study were classified into two groups: post-operative patients with bladder cancer were used pirarubicin(THP);31 heathly volunteers.The voided urine of all the patients in before,6weeks,6 months,12 months post perfusion were recovered selectively.HGF and NMP22 kits were used to detect bladder cancer.Voided urine cytology(VUC) was used to compare the sensitivity and specificity of the screening test.Result:There were 11 cases who relapsed in 92 patients with perfusion in 12 months.The level of HGF and NMP22 decreased with the prolong of perfusing time.There were mostly increased in the relapse of bladder cancer.The sensitivity and specificity of HGF,NMP22 and VUC were 91%,73%,45% and 58%,48%,98% respectively.The VUC has the lowest sensitivity among the screening tests.The HGF and NMP22 with the sensitivity can be an adjunct to cytology for evaluating relapse of bladder cancer.Conclusion:The HGF and NMP22 test has a better correlation with the relapse of the bladder cancer.They might be promising tools for screening and early diagnosing bladder cancer.