Monodispersed CuSe Sensitized Covalent Organic Framework Photosensitizer with Enhanced Photodynamic and Photothermal Effect for Cancer Therapy

Attribute to its simplicity, non-invasiveness feature and excellent therapeutic effect, phototherapy received considerable interests recently. The combination of photothermal therapy (PTT) and photodynamic therapy (PDT) holds great promise in the treatment of tumors, and in order to achieve satisfactory antitumor efficacy, suitable photosensitizers are prerequisite. In this paper, highly monodispersed COF-LZU-1 nanoparticles were firstly prepared by a mild solution-phase synthesis method at room temperature. The as-synthesized non-porphyrin containing COF nanoparticle was employed as a novel photosensitizer for PDT, which exhibited excellent photodynamic effect under 650 nm or 808 nm laser irradiation. And then CuSe nanoparticles, an ideal photothermal agent, were successfully conjugated with COF to form a dual functional photosensitizer for phototherapy. The resultant COF-CuSe platform possesses excellent synergistic photothermal and photodynamic effect. The in vitro and in vivo experiments indicated an ...