ESTUDO DE EQUIVALÊNCIA FARMACÊUTICA DE COMPRIMIDOS DE CLORIDRATO DE METFORMINA GENÉRICOS E SIMILARES

Metformin is an oral hypoglycemic of the class of biguanides widely used in the treatment of type 2 diabetes mellitus. Pharmaceutical equivalence studies are aimed at evaluating some quality parameters of medicinal products by comparative analysis between the test drug (s) and the reference dosage form. Thus, the purpose of this study was to evaluate the pharmaceutical equivalence of two brands of generic drug and two brands of similar drug against the reference metformin hydrochloride tablets 850mg. The following tests were carried out: weight variation, friability, disintegration, assay and dissolution. The tested samples were approved in all the tests, meeting the criteria recommended by the Brazilian Pharmacopoeia 5a edition. Thereby, it has been found that all drugs tested are pharmaceutically equivalent to the reference product.