Crystal structure and antibacterial activity of scandenone (warangalone) from Erythrina plants

Abstract Scandenone (warangalone) is a flavonoid found in Erythrina species and other plant genera. It has been connected with physiological processes in insects, human cells and bacteria. In this article, an overview of the biological importance of this compound is provided. A detailed analysis of its crystal structure and antibacterial properties were investigated. The experimental study was supplemented using density functional theory (DFT) and quantitative structure-activity relationship (QSAR) methods. Scandenone proved most potent against Mycobacterium smegmatis (mc2 155) with MIC below 1 μg/mL. In general, it was more potent against Gram-positive bacteria. Scandenone may be a potential tuberculosis medication.