Prognostic Markers in Resected Non–Small-Cell Lung Cancer: An Patients with 5 Year Follow-Up

Abstract We performed a retrospective analysis of potential prognostic markers in 260 patients with surgically resected stage I and II non–small-cell lung cancer (NSCLC) with a minimum 5-year follow-up. Cox proportional hazard models and Wilcoxon tests were employed to analyze the effect of patient characteristics on survival and disease-free survival (DFS). In the univariate analysis, the following were significant predictors of shorter overall survival: N-stage (N1 vs N0) (p bcl-2 expression (positive vs negative) (p= 0.03); age (> 63.5 vs K-ras mutation, and immunohistochemistry staining for Lewis y , p53, Rb, microvessel count, HER2, E-cadherin and neuroendocrine markers did not reach statistical significance. In multivariate analysis, the following predicted for shorter overall survival: N-stage (p bcl-2 (p = 0.05); and for DFS, N-stage (p