Protégé-2000 as authoring environment for Clinical Practice Guidelines within the HELEN-Project

Methods Since Protege does not contain sufficient methods for designing ontologies, we used the Model-based Incremental Knowledge Engineering Process (MIKE). This is a method for developing knowledge based systems based on the Spiral Model of Software Development. Therefore the development consisted of four tasks: • analysis of requirements • design or refinement of the ontology • implementation of an initial knowledge acquisition tool and its extensions • evaluation by entering examples and test usage of the encoded information.