Anaesthesiologic problems about hyperthermic intraoperative intraperitoneal chemotherapy

The literature considers hyperthermic intraoperative intraperitoneal chemotherapy a safe and effective procedure for peritoneal carcinomatosis, but a technical improvement is necessary. Regional chemiotherapy anticipates the "downfall" of tumoral cells in the peritoneum. The Authors considered 5 patients - female, age 27-45 years, ASA 2 - operated of peritonectomy in ovaric neoplasia with peritoneal metastasis. The hyperthermic intraoperative intraperitoneal chemotherapy has been made at the end of the surgery with a hot solution (43°C): 3000 ml of dextrose 1,5% with mytomicina C25 mg e cysplatino 75mg/m 2 . We considered variation of emodinamic parametres (blood pressure, central venous pressure, stroke volume, etc.) and biochemical parametreas (Na, K, CI, CO 2 , etc.). These parametres have been correlated with some complications: fistula, anastomotic leakage, pancreatitis and postoperative bleeding.