The juvenile antisocial brain : brain imaging studies in clinically antisocial youth with nascent phychopathic traits
2018
The work presented in this thesis provides important new
clues on the neurobiology of juvenile psychopathic traits in clinically
antisocial juveniles. The data specifically shows that these traits are
ostensibly underpinned by highly specific corticolimbic network dysfunctions,
in which amygdala subregional networks seem particularly relevant. That data
additionally suggests that some of these network dysfunctions and their
associated neurocognitive deficits are possibly driven by alterations in the
oxytocinergic system. Interestingly, the data also provides preliminary
neurobiological support for the scientific utility of using juvenile
psychopathic traits to subtype the highly heterogeneous group of clinically
antisocial teens. While these data may represent important new steps towards
a deeper understanding of clinical youth antisociality, their significance
has to be evaluated by replication studies that further explore and validate
the findings presented here.
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