Preparation and in vitro and in vivo characterization of valsartan loaded eudragit nanoparticles

The aim of the present work was to prepare and investigate the valsartan nanoparticles. nanoparticles were prepared by nanoprecipitation method and the various formulations were prepared by optimizing. The prepared nanoparticles were characterized by FTIR, DSC, SEM, particle size analysis, In vitro diffusion and in vivo studies are been performed. The particle sizes of the prepared nanoparticles were ranging from 175 to 232 nm. From three formulations, F2 formulation showed best release of 60.38 % at the end of 24th h. In vivo studies revealed that in case of free drug, 40.9 mcg/ml drug of maximum dose was recovered but in case of nanoparticles the dose recovered in serum was 16.02 mcg/ml after 6th h. The formulation stored at 4o ± 1 oC was more stable compared to the other temperatures. These studies suggest that the feasibility of formulating valsartan loaded Eudragit L 100 nanoparticles for the treatment of hypertension by enhancing the bioavailability.