A Randomized Trial Comparing Seed Loss and Displacement of Specially Engineered Coated Seeds to Standard Uncoated Loose Seeds

dominant and recessive. Combined p values were calculated for the discovery and replication studies using Fisher’s method after filtering on agreement in effect direction. Results: Several genomic regions were identified that contained clusters of SNPs with combined p values reaching significance (1E-05 after correction for multiple comparisons). Interestingly, some of the significant SNPs were more strongly associated with early onset of urinary morbidity (between 1 year and 3 years post-treatment), whereas other significant SNPs showed a stronger association with later onset of urinary morbidity (between 3 years and 5 years post-treatment). Conclusions: This study identifies several potential predictive genetic variants that are associated with urinary morbidity following prostate radiation therapy and could potentially be used to predict the severity of urinary symptoms for individuals receiving radiation therapy for prostate cancer. Author Disclosure: S. Kerns: None. R. Stock: None. N. Stone: G. Consultant; Centocor Ortho Biotech Inc. L. Rath: None. H. Ostrer: None. B. Rosenstein: None.