Antibacterial Activity Investigation of Human Semenogelin I Derived Peptides
2009
SgI-29 is a newly characterized antibacterial peptide derived from
human semenogelin I. Using SgI-29 as model, 4 peptides with different
length were synthesized. Physico-chemical characteristics and structure
prediction of SgI-29 and its derived peptides were analyzed by software
packages and helix-wheel plot. The antibacterial activities of SgI-29
and its derived peptides against Escherichia coli ATCC 25922 and
Pseudomonas aeruginosa ATCC 27853 were determined. The
structure-function relationship of SgI-29 and its derivatives was
analyzed. Our results indicated that SgI-22 has the strongest
antibacterial activities against the tested bacteria among the
synthetic peptides and might be used as a good model for the structure
optimization.
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