DNA Markers from Genome-Wide Association Studies of Cardiovascular Diseases

This paper presents the results of selecting the most promising single nucleotide polymorphisms associated with cardiovascular diseases in genome-wide association studies. Twenty such loci were identified. For eight of those loci, protocols for discrimination of the corresponding allelic variants with a real-time polymerase chain reaction (TaqMan) were developed and used for genotyping a sample of Russian individuals from Moscow.