PO259 Population-based study of prognostic value and control of nocturnal bp after tia and stroke

Background In previous studies of treated hypertensives, nocturnal-BP was a stronger predictor than daytime-BP of residual risk of stroke and cardiovascular events (CVEs). However, it is unclear whether nocturnal hypertension (NH) explains residual risk of recurrent stroke after TIA/ischaemic stroke. Methods In a population-based study (Oxford Vascular Study), consecutive patients with TIA/non-disabling stroke had 24 hour ambulatory BP-monitoring (ABPM) at one-month follow-up. Mean daytime and mean night-time-BP were related to risk of recurrent stroke and cardiovascular events on follow-up after age/sex-adjustment. NH was defined as asleep mean SBP ≥120 mmHg and daytime-hypertension (DH) as awake mean SBP ≥140 mmHg. Results Among 1035 patients with ABPM (mean/SD age 68.67/12.74), 372 (36.4%) had residual NH and 190 (18.4%) had residual DH (p Conclusion Residual nocturnal hypertension was more common than daytime hypertension, but it was not a major risk factor for stroke or cardiovascular events.