A kind of synthetic method of DRV key intermediate

The present invention is the synthetic method of a kind of DRV key intermediate, with 1S (1 benzyl 3 chlorine 2 carbonyl propyl group) t-butyl carbamate as raw material, with chiral carbonyl reducing catalyst { N [3 (η 6 phenyl) propyl group] [(1S 2S) 1,2 diphenyl 14 methyl benzenesulfonamide (kN) ethyl 2 amino (kN)] } ruthenium (II) catalytic hydrogenation prepares DRV key intermediate 1S, 2S (1 benzyl 3 chlorine 2 hydroxypropyl) t-butyl carbamate.The synthetic method route that the present invention provides is simple, and reaction condition is gentle, and by experimental verification, its yield is high and optical purity is high.React rear 1S, 2S (1 benzyl 3 halogen 2 hydroxypropyl) t-butyl carbamate post processing is simple, by filtering the separation that just can complete chiral carbonyl reducing catalyst, recycled solvent, catalyst can recycle, low cost, meet the theory of Green Chemistry, solve the three waste discharge problem of 1S in prior art, 2S (1 benzyl 3 halogen 2 hydroxypropyl) t-butyl carbamate, reduce cost.