New broad-spectrum parenteral cephalosporins exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Part 3: 7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido] cephalosporins bearing 4-[3-(aminoalkyl)-ureido]-1-pyridinium at C-3'

Hidenori Yoshizawa,Tadatoshi Kubota,Hikaru Itani,Kyoji Minami,Hideaki Miwa,Yasuhiro Nishitani

New broad-spectrum parenteral cephalosporins exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Part 3: 7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido] cephalosporins bearing 4-[3-(aminoalkyl)-ureido]-1-pyridinium at C-3'

2004

Hidenori Yoshizawa
Tadatoshi Kubota
Hikaru Itani
Kyoji Minami
Hideaki Miwa
Yasuhiro Nishitani

Abstract Among the prepared C-3′ substituted-pyridinium cephalosporins, a series of 7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido] cephalosporins bearing 4-[3-(aminoalkyl)-ureido]-1-pyridinium at C-3′ showed highly potent antibacterial activity against MRSA and Pseudomonas aeruginosa.

Keywords:

Pyridinium Compounds
Meticillin
Pseudomonadaceae
Methicillin-resistant Staphylococcus aureus
Staphylococcus aureus
Antibacterial activity
Stereochemistry
Microbiology
Biochemistry
Chemistry
Cephalosporin
Pseudomonas aeruginosa
antibacterial agent

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