Molecular dynamics complemented by site-directed mutagenesis reveals significant difference between the interdomain salt bridge networks stabilizing oligopeptidases B from bacteria and protozoa in their active conformations

Dmitry E. Petrenko,A. G. Mikhailova,Vladimir I. Timofeev,Yulia К. Agapova,David M. Karlinsky,Aleksandr S. Komolov,D.A. Korzhenevskiy,Anna V. Vlaskina,Lev D. Rumsh,Tatiana V. Rakitina

Molecular dynamics complemented by site-directed mutagenesis reveals significant difference between the interdomain salt bridge networks stabilizing oligopeptidases B from bacteria and protozoa in their active conformations

2019

Dmitry E. Petrenko
A. G. Mikhailova
Vladimir I. Timofeev
Yulia К. Agapova
David M. Karlinsky
Aleksandr S. Komolov
D.A. Korzhenevskiy
Anna V. Vlaskina
Lev D. Rumsh
Tatiana V. Rakitina

AbstractOligopeptidases B (OpdBs) are trypsin-like peptidases from protozoa and bacteria that belong to the prolyl oligopeptidase (POP) family. All POPs consist of C-terminal catalytic domain and N...

Keywords:

Bacteria
Site-directed mutagenesis
Protozoa
Salt bridge
Biochemistry
Molecular dynamics
Chemistry
significant difference
Oligopeptidase
Serratia proteamaculans

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