Dynamic erasure of X chromosome upregulation during iPSC reprogramming and in the inner cell mass

Recent studies have provided substantial evidence supporting Ohnos hypothesis that upregulation of active X chromosome genes balances the dosage relative to autosomal genes. Here, we found the evidence for erasure of active X-chromosome upregulation upon reactivation of inactive X in female cells during iPSC reprogramming and in the inner cell mass of mouse blastocyst. Moreover, our analysis revealed that the kinetics of erasure of X upregulation is tightly linked with the dynamics of X reactivation. O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=194 SRC="FIGDIR/small/424181v1_ufig1.gif" ALT="Figure 1"> View larger version (34K): org.highwire.dtl.DTLVardef@162f74dorg.highwire.dtl.DTLVardef@5a1b69org.highwire.dtl.DTLVardef@1bdbefeorg.highwire.dtl.DTLVardef@46290d_HPS_FORMAT_FIGEXP M_FIG C_FIG