Computational Models of Pathophysiological Glial Activation in CNS Disorders

Glial cells, in general, and astrocytes, in particular, are indispensable for homeostatic regulation of neural function, which positions these non-neuronal cells in the limelight of CNS pathologies. The renewed interest in glial physiology and the advent of new experimental methods motivated the development of computational models of glial cells. In this contribution, we review the development and challenges of computational models of pathophysiological glial activation in CNS disorders.