Omics analysis and industrial application prospects of lignocellulose-degrading actinomycetes
2017
Actinomycetes , a group of Gram-positive bacteria
with high GC contents, play important roles in hyperthermal lignocellulose
degradation in terrestrial habitats. A functional genomics analysis
revealed that lignocellulose-degrading actinomycetes have more cellulases
than hemicellulases and pectinases. Additionally, the enzymes capable
of degrading cellulose were mainly cellobiohydrolases belonging to
glycoside hydrolase family 6, with a small number of cellulases belonging
to glycoside hydrolase families 9 and 48. In addition to glycoside
hydrolases, large numbers of polysaccharide monooxygenases from auxiliary
activity family 10 were also identified. Therefore, actinomycetes
can efficiently degrade crystalline cellulose by continuous hydrolysis
and oxidation mechanisms. Furthermore, some of these enzymes with
multiple structural domains can be secreted quickly into the extracellular
environment through the twin-arginine translocation system. These
lignocellulolytic enzymes have excellent properties, such as high
enzyme activity and high temperature and alkali resistance. Therefore,
the characteristics and advantages of these actinomycetes in lignocellulose
degradation and secondary metabolite production make them well suited
for industrial applications.
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