NMR study of the p-DNA duplex [(4"->2")-3"-desoxyribopyranosyl-(m5CGDDTTm5CG)2] and comparison with its p-RNA analogue
2001
The detn. of the soln. structure of small non-natural oligopeptides and oligonucleotides by NMR, which is one of the main research topics of our group, is illustrated on the example of an 8-mer p-DNA duplex. P-DNA, the 3'-desoxy analog of p-RNA, forms an highly selective pairing system but its pairing strength is less than that of analogous p-RNA sequences. The NMR study reveals that the backbone of p-DNA corresponds more closely to the conformation predicted for pentapyranose nucleic acids by qual. conformational anal. than p-RNA. [on SciFinder (R)]
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
1
References
2
Citations
NaN
KQI