Dual Role of Rac in the Assembly of NADPH Oxidase, Tethering to the Membrane and Activation of p67 phox

From the ‡Julius Friedrich Cohnheim-Minerva Center for Phagocyte Research and the Ela Kodesz Institute of Host Defense against Infectious Diseases, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel, the §Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, the ¶Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom, and the Laboratoire DBMS⁄BBSI, CEA Grenoble, 38054 Grenoble Cedex 9, France