Effects of barium on stimulus-induced rises in [K+]o in juvenile rat hippocampal area CA1.
1998
IMMATURE glia may not be able to buffer K + ions released during neuronal activity. Therefore, we investigated entorhinal-hippocampal slices of juvenile rats (ages P15-18 and P22-26) using a perfusion medium containing 2 mM BaCl 2 in order to block glial inward rectifying and leak potassium channels. In contrast to adult animals, rises in [K + ] o in slices from juvenile animals elicited by repetitive alvear stimulation were not augmented by Ba 2+ . Ba 2+ effects on fast field potentials, slow field potentials and the applied current sink source distribution were roughly similar as in adult rats. We conclude that the capacity to buffer large quantities of K + ions by mechanisms involving Ba 2+ -sensitive K + channels has not yet developed in juveniles.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
20
References
16
Citations
NaN
KQI