Analysis of Serum Creatinine Level and Contrast Volume in Contrast Induced Nephrophaty Incidence after Percutaneus Coronary Intervention

The increase of percutaneous coronary intervention (PCI) in cardiovascular patients through the administration of contrast agents leads to a potential risk of contrast induced nephrophaty (CIN) incidence. This study aims to analyze the particular level of serum creatinine through the administration of contrast agents and specific contrast volumes in CIN incidence after PCI. The experimental design used in this study was cross sectional design. The total samples were 30 patients who underwent percutaneus coronary intervention (PCI) at the Cardiovascular Center Unit of Dr. Wahidin Sudirohusodo Hospital in Makassar Municipality. The statistical test used to analyze serum creatinine levels before and after PCI was Mann-Whitney U test and contrast volumes were compared based on results of the analysis of serum creatinine levels. Results of the analysis of serum creatinine levels after PCI indicated that 10 patients (33.33%) experienced CIN incidence and their serum creatinine levels were higher than other remaining patients at the normal level of serum creatinine. The increase of serum creatinine levels before and after PCI showed statistically significant difference between the CIN group and the non-CIN group. On average, administration of contrast volumes at >50 mL and frequency of CIN incidence was found in diagnosed patients who experienced the coronary artery disease (CAD) at both grade 1 and 3. Results of this study proved that PCI increased potential risk of CIN incidence and provided a novel data to be used for the elucidation in subsequent health studies,  in which contrast volume at <50 mL and diagnosis of the various grades of CAD could be used as a sustainable consideration for the administration of contrast agents.