Historical Evolution and Development of the Threshold (TTC) of Toxicological Concern
2013
The threshold of toxicological concern (TTC) is a concept that refers to the establishment of a level of exposure for all chemicals, below which there would be no appreciable risk to human health. The TTC method has been applied for nearly half a century since it was proposed, and has experienced a continuous improvement and development process. The establishment, development and improvement of TTC method were discussed. TTC method was originally developed to determine the threshold of safety in food materials. Since then, the non-carcinogenic oral toxicity endpoint of no significant effect level (NOEL) was analyzed to develop a structural class-based multi-scale TTC which was then adopted by Food Additives of FAO/World Health Organization (FAO/WHO) Joint Expert Committee (JECFA) and the European Food Safety Authority (EFSA) with development and improvement. The TTC approach is in wide application to assess the risk of chemicals at low exposure levels, which avoids multiple unnecessary, overly detailed studies, as well as a wide range of toxicological experiments. The TTC method also provides a feasible way for the risk assessment of chemical substances that the amount is very low but lack of a complete toxicity data.
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