Miconazole nitrate-loaded microparticles for buccal use: immediate drug release and antifungal effect.
2017
The aim of this study was to prepare and to evaluate Eudragit L100
and Gantrez MS-955 microparticles containing miconazole nitrate for buccal
delivery. Microparticles were prepared by spray-drying method in order to
achieve high encapsulation efficiency and increased drug solubility. The
microparticles were obtained containing 10% and 20% (w/w) of drug:polymer
ratio using Eudragit L100 (E10 and E20), Gantrez MS-955 (G10 and G20) or
their combination (EG10 and EG20). The influence of formulation factors
(drug:polymer ratio, type of polymer) on yield, encapsulation efficiency,
particle size, Fourier-transformed infrared spectroscopy (FTIR), X-ray
diffraction, differential scanning calorimetry, in vitro drug release and
antifungal activity were investigated. Acceptable yield, micrometer-sized
particles and drug-loading efficiencies higher than 89% were obtained. No
change in FTIR assignments was recorded after the microencapsulation
procedure. X-ray and differential scanning calorimetry studies revealed
amorphous/non-crystalline formulations. Miconazole nitrate-microparticles
provided a remarkable increase of dissolution rate for this drug. Miconazole
nitrate and G10, G20, EG10, and EG20 microparticles were fitted to
biexponential kinetic model while E10 and E20 microparticles were fitted to
monoexponential kinetic model. The antifungal assay demonstrated that
miconazole nitrate-loaded microparticles provided the same anti-Candida
albicans activity of the pure drug. These results indicate that miconazole
nitrate-loaded microparticles are feasible carriers for increased release of
this antifungal drug at buccal environment.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
3
Citations
NaN
KQI