99Tcm-MIBI and 18F-FOG dual isotope simultaneous acquisition SPECT in determination of myocardial viability

Objective Viable myecardium is important to patients with coronary artery diseage.The obiecfive of this study was to evaluate the value of dual-isotope simultaneous acquisition SPECT(DISA SPECT)with 99Tcm-methoxyisobutylisonitrile (MIBI) and 18F-fluorodeoxyglueose (FDG) in detecting viable myocardium(VM).Methods Twenty-one patients with regional wall motion abnomudities(RWMA) based on routine echocardiography underwent DISA-SPECT,coronary angiography and percutaneous coronary intervention(PCI).Imaging and analysis of the left ventrieular myocardial perfusion status were performed according to the 16-segment models proposed by American Society of Echocardiography.The wall motion of every LV segment was observed by echocardiography after 1,3,6 months.The images of DISASPECT were analyzed semi-quantitatively.The"gold standard"for true viability was improvement of wall motion of the vertricular segment after PCI.Results There were 105 viable myocardial segments and 51 non-viable myocardial segments according to the"gold standard"criterion.The sensitivity,specificity.positive predict value,negative predict value and accuracy of DISA-SPECT in detecting viable myoeardium were 93.3%(98/105),82.4%(42/51),91.6%(98/107),85.7%(42/49),89.7%(140/156),respectively.Conclusion DISA-SPECT is a valuable technique to detect viable myocardium in patients with coronary artery disease. Key words: Coronary disease; Tomography; emission-computed; single-photon; MIBI; Deoxyglucose