A highly chemo- and enantioselective nitroaldol reaction of haloenals: preparation of chiral functionalized allylic alcohols
2012
Abstract An efficient L1 /Cu(II)-catalyzed highly chemoselective and enantioselective nitroaldol reaction of α- or β-haloenals with nitromethane has been described. The reaction delivered chiral functionalized allylic alcohols bearing halo and nitro groups with excellent results (up to 94% yield and 99% ee) under mild reaction conditions.
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