Molecular Targets: Inhibition of Tumor Cell Invasion

Gliomas are solid brain tumors that arise from glial cells. According to World Health Organization (WHO), they are classified in four grades based in their histological features. Grades I and II are considered low-grade gliomas and grades III and IV, malignant gliomas. In the United States, each year more than 22,000 people are diagnosed with malignant glioma, representing almost 70% of all malignant primary brain tumors in adults (Wen & Kesari, 2008; CBTRUS 2010; Jones & Holland, 2010).