Imbalance in Chloride Homeostasis in Substantia Nigra Reticulata:A Novel Pathogenesis of Hepatic

Hepatic encephalopathy (HE) is a neuropsychiatric syndrome, that frequently occurs in chronic liver disease. Its clinicalmanifestations range from minor sleep disturbances, changes inpersonality and motor activity, to overt deterioration of cognitive functions,motor coordination, decreased consciousness and coma.The pathogenesis ofHE is not been fully understood and manyfactorsmayaffect its development.