Observation of the application of fluorouracil sustained release implant in advanced gastric cancer surgery

Objective In recent years, as people have attached importance to the application of regional chemotherapy in the surgery of advanced gastric cancer, the research of fluorouracil sustained release implant, a regional chemotherapeutic drug, is on the increase.Fluorouracil sustained release implant is a new anti-carcinogen combined with fluorouracil, a conventional chemotherapeutic drug, through polymeric scaffolds and rete technology.It can be implanted into cancerous lesion area, as its slow-releasing potential and targeting property will give full play to the antitumor effect of fluorouracil, which can decrease the rate of local recurrence and metastasis of gastric cancer and prolong the life span of the patients.Based on the study of the researches on fluorouracil sustained release implant, a summary was made from different perspectives: basic medicine, pharmacy and clinical medicine.It may have reference value for clinical application and further study. Key words: Fluorouracil sustained release implant: intraperitoneal chemotherapy; Advanced gastric cancer