Plasmatic presepsin (sCD14-ST) concentrations in acute pyelonephritis in adult patients

Abstract Introduction Presepsin (sCD14-ST) is an emerging biomarker for infection. We hypothesized that presepsin could specifically increase during acute pyelonephritis and correlate with severity. Methods We compared presepsin values in patients with acute pyelonephritis and controls, and we assessed its capacity to predict bacteraemia and admission in patients. Results In 312 patients with acute pyelonephritis (median age 33 years), presepsin concentrations were higher than in controls (476 vs 200 ng/L, p p p p  = 0.87) and less accurate than PCT (AUC = 0.78, p p  = 0.26) and PCT ( p  = 0.18). Conclusion Presepsin is a valuable biomarker to detect patients with acute pyelonephritis. However, it presents mild performance to predict bacteraemia and the need for admission, and offers no advantage as compared to CRP and PCT.