An analysis of relationship between the severity of coronary artery lesion and risk factors of cardiovascular events in Tianjin

OBJECTIVE: to evaluate the correlation between the severity of coronary artery lesion and multiple risk factors of events of coronary heart disease (CHD) in patients with coronary arteriography (CAG) in Tianjin. METHODS: A retrospective study was conducted. One thousand six hundred and twenty-nine patients with CHD as diagnosed with CAG in Tianjin Chest Hospital were enrolled in the study. Using the SYNTAX score to evaluate the outcomes of CAG, The patients wer divided into three groups, i.e. low (0-22, n=962), medium (23-32, n=446) and high (≥ 33, n=221) score groups. The relationship between the severity of CHD patients analysis. RESULTS: The single factor analysis results showed that the severer the coronary artery lesion, the higher the SYNTAX score, the higher the proportion of patients having one of single risk factors (old, male, smoking, hypertension, type 2 diabetes mellitus, blood lipid abnormality), the lower the high density lipoprotein cholesterol (HDL-C), and the higher the low density lipoprotein cholesterol (LDL-C), total cholesterol (TC) level, fibrinogen (FIB) content, and body mass index (BMI, all P<0.01). The logistic regression analysis showed that male, old age, hypertension, typed 2 diabetes mellitus, TC were the independent risk factors in aggravating the severity of CHD. Hypertension [ odds ration (OR)=3.947, 95% confidence interval (95% CL) 1.45-10.704, P<0.001] and type 2 diabetes mellitus (OR=5.760, 95% CI 2.549-13.018, P<0.001) were the two most prominent predictors for CHD, while HDL-C was the protective factor for CHD (OR=0.541, 95% CI 0.295-0.992, P=0.992, P=0.004). CONCLUSION. The severity of CHD was closely related to CHD was closely related to various risk factors, among them hypertension and type 2 diabetes mellitus were the most predominant risk factors of CHD. Therefore it should be emphasized that clinicians should control blood pressure, blood glucose, and also blood lipid level in CHD patients to prevent cardiac event.