A Study of The Effect of Antioxidant Status on the Outcome of Malignant Gliomas

Objective:To explore the relationship of the effect of antioxidant status of patients with malignant gliomas at the time of their admission to a tertiary care hospital and the clinical condition after a post operative follow up over a period of two years. Methods:Several antioxidant enzymes like erythrocytic glutathione reductase, glutathione peroxidase,catalase,superoxide dismutase,plasma ceruloplasmin,antioxidant vitaminsA,E and C and lipid peroxidation products like erythrocytic thiobarbituric acid reacting substances and plasma conjugated diene swere analyzed both in controls and glioma patients. Results: It was observed that patients who exhibited an overall higher turn over of an-tioxidants presented with recurrence. Conclusion: Free radical toxicity may adversely affect the out come of such cancer patients.