Methods of treatment and prevention of diseases and neurodegenerative disorders

A pharmaceutical composition comprising 1- (N- (2- (diethylamino) ethyl) -N- (4- (4-trifluoromethylphenyl) benzyl) -aminocarbonilmetil) - 2- (4-fluorobenzyl) thio-5,6-trimetilenopirimidin- 4-one (SB480848) or a salt pharmaceutically acceptable, and a pharmaceutically acceptable carrier for use in the treatment and / or prevention of a disease or neurodegenerative disorder, wherein the neurodegenerative disorder is vascular dementia.