The PRDX2 gene is transcriptionally silenced and de novo methylated in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma.

To the editor: In a recent issue of Blood , Agrawal-Singh et al reported the identification of PRDX2 (peroxiredoxin 2) as a novel tumor suppressor gene in acute myeloid leukemia (AML).[1][1] The authors observed recurrent histone H3 deacetylation and DNA hypermethylation at the PRDX2 promoter