Septicemia after Chemotherapy for Acute Lymphoblastic Leukemia: A Multicenter Study Chinese Children Cancer Group (CCCG)-ALL-2015

Introduction: Septicemia is one of the common complications after chemotherapy for acute lymphoblastic leukemia (ALL) and is also an important cause of treatment related mortality and treatment failure. A multicenter study CCCG-ALL-2015 was conducted in China and factors associated with septicemia and mortality were studied. Methods: Patients participated in CCCG-ALL-2015 study from January 2015 to December 2017 were included in this study. Patients with documented septicemia were identified from the Database of Central Data Center. Additional data were then collected from participation centers, including associated co-morbidity, blood counts before septicemia and infection preventive measures. Results: A total of 4080 patients were recruited from 18 centers. There were 527 patients with septicemia identified (12.9%). The Intermediate risk (IR)/ High risk (HR) group(n=1930) had significantly higher incidence of septicemia as compared with Low risk (LR) group (n=2150), 17.15% vs 9.12% (p Conclusion: Overall the incidence and pattern of septicemia in this multicenter study in China was similar to reports of western countries. The septicemia related mortality rate was low. However there was marked variation in the incidence of septicemia among the centers, further studies are required to validate factors such as infection preventive measures which might influence the septicemia incidence. Disclosures No relevant conflicts of interest to declare.