Comparison of oxycodone with sufentanil for early postoperative analgesia after video-assisted laparoscopic hysteromyoma surgery

Objective To compare oxycodone with sufentanil for early postoperative analgesia after video-assisted laparoscopic hysteromyoma surgery. Methods Ninety patients, scheduled for selective hysterectomy or myomectomy performed via video-assisted laparoscope in the Affiliated Hospital of Qingdao University from January 2016 to January 2017, ASA Ⅰ or Ⅱ, aged 30-65 yr, were divided into three groups: oxycodone group (group O), sufentanil group (group S) and normal saline group (group NS), 30 cases in each group. All patients were induced and maintained by target controlled infusion of propofol. Oxycodone 5 mg, sufentanil 5 μg or equal volume of normal saline were given respectively at 15 min before the end of operation in the three groups. Anesthesia time, operation time, breathing recovery time, extubation time and waking time after extubation were recorded. HR, MAP, RR, SpO2, VAS, Ramsay score, the requirement for rescue analgesic and adverse reactions were also recorded at immediately entering post anesthesia care unit (PACU), and after30 min, 60 min, 90 min. Results Compared with group NS, breathing recovery time, extubation time and waking time after extubation were significantly longer. Ramsay score increased at each time point, and the cases of adverse reactions increased significantly in group S (P<0.05), while there was no significant difference between group O and group NS. VAS, HR, MAP and the requirement for rescue analgesic decreased at each time point in group O and group S as compared with group NS (P<0.05), while no significant difference between group O and group S. Conclusion Intravenous injection of oxycodone at 15 min before the end of operation can effectively alleviate acute pain after laparoscopic hysterectomy or myomectomy. Compared with sufentanil, the sedative effect and respiratory inhibition are weak, and the recovery period of general anesthesia can be passed stably and safely. Key words: Oxycodone; Sufentanil; Uterine neoplasms; Pain, postoperative; Surgical procedures; Laparoscopes