Shedding X-ray light on the role of magnesium in the activity of M. tuberculosis salicylate synthase (MbtI) for drug design

Matteo Mori,Giovanni Stelitano,Arianna Gelain,Elena Pini,Laurent R. Chiarelli,José Camilla Sammartino,Giulio Poli,Tiziano Tuccinardi,Giangiacomo Beretta,Alessio Porta,Marco Bellinzoni,Stefania Villa,Fiorella Meneghetti

Shedding X-ray light on the role of magnesium in the activity of M. tuberculosis salicylate synthase (MbtI) for drug design

2020

Matteo Mori
Giovanni Stelitano
Arianna Gelain
Elena Pini
Laurent R. Chiarelli
José Camilla Sammartino
Giulio Poli
Tiziano Tuccinardi
Giangiacomo Beretta
Alessio Porta
Marco Bellinzoni
Stefania Villa
Fiorella Meneghetti

The Mg2+-dependent salicylate synthase (MbtI) from Mycobacterium tuberculosis is a key enzyme involved in the biosynthesis of siderophores. Because iron is essential for the survival and pathogenic...

Keywords:

Biochemistry
Siderophore
Chemistry
Tuberculosis
Mycobacterium tuberculosis
ATP synthase
Magnesium
Drug
Enzyme
Biosynthesis

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