Studies in formulation of ampicillin dispersible tablets

Dispersible ampicillin tablets were formulated employing a blend of disintegrating agents like sodium starch glycolate, microcrystalline cellulose and starch and were investigated. The tablets were prepared by wet granulation technique. Ethanolic solution of ethylcellulose and isopropyl alcoholic solution of polyvinyl pyrrolidone were used as granulating agents. The granules showed satisfactory flow properties and compressibility. A concentration of disintegrants blend in the range of 15-20% was found to comply with disintegration test IP. All the tablets showed acceptable pharmaceutical properties. Tablets prepared with the blend of sodium starch glycolate (20mg), microcrystalline cellulose (10mg) and starch (10mg) exhibited quicker disintegration. Tablets of batch F-I (blend containing sodium starch glycolate 20mg and polyvinyl pyrrolidone as granulating agent), the successful formulation of the study, exhibited 98.10% drug dissolution within 45 minutes.