Somatic mutation of PTEN in vulvar cancer.
2000
PTEN, a candidate tumor suppressor gene located at
chromosome 10q23.3, has been shown to be mutated in ∼40% of
endometrial cancers. Such mutations have also been identified in
endometrial hyperplasia, indicating that inactivation of the
PTEN tumor suppressor gene is an early event in the
genesis of some endometrial cancers. In this study, we have extended
the analysis of PTEN in gynecological cancer to include
adenocarcinoma of the cervix and vulvar carcinomas. Microdissected
tissue (including normal tissues), preneoplastic, and neoplastic
lesions were analyzed from 9 patients with cervical cancer and 10
patients with vulvar cancer. Only 1 cervical adenocarcinoma displayed a
PTEN mutation. In contrast, five of eight vulvar
carcinomas studied harbored PTEN mutations. Alterations
were identified in carcinoma in situ as well as squamous
cell carcinoma of the vulva. In two patients, PTEN
mutations were identified in mucosal regions with mild or focal
dysplasia. These results suggest that PTEN is frequently
altered in vulvar carcinomas and can be found associated with early
dysplastic changes in vulvar mucosa.
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