Risk factors for ischemic stroke A hospital-based reduced kidney function in patients with acute retrospective case series study

Objective To investigate the risk factors for reduced renal function in patients with ischemic stroke. Methods The medical records of patients with ischemic stroke were analyzed retrospectively. They were divided into normal renal function group and reduced renal function group. Reduced renal function was defined as estimated glomerular filtration rate （eGFR） 〈60 ml/（min-1.73 m2）. Multivariate logistic regression analysis was used to identify the risk factors for reduced renal function in patients with ischemic stroke. Results A total of805 patients with ischemic stroke were enrolled in the study. 8. 8% of patients had a reduced renal function. There was no significant differences in the proportion of patients with mild and moderate neurological deficit between the reduced renal function goup and the normal renal function group （all P〉 0. 05）, however, the proportion of patients with severe neurological deficit was significantly higher than that in the normal renal function group （8.4% vs. 2. 6%, X2 =5. 573, P =0. 017）. The proportion of small artery occlusion in the reduced renal function group was significantly higher than that in the normal renal function group （66. 2% vs. 46. 5%, X^2 =9.962, P = 0. 002）, and the proportion of large artery atherosclerosis was sigrdficantty lower than that in the normal renal function group （19. 7% vs. 43.5%, X^2 = 15. 045, P = 0. 000）. Multivariate logistic regeession analysis indicated that old age （odds ratio [OR] 3.301, 95% confidence interval [CI], 1. 575 to 6. 918; P= 0. 002） was the most important independent risk factor for reduced renal function, then was female （OR, 2. 291, 95% CI 1. 355 to 3. 872; P =0. 002） and hyperlipidemia （OR, 2. 527, 95% CI 1. 095 to 5. 831; P =0. 030）. Conclusions Reduced renal function in patients with ischemic stroke is strongly associated with old age, female, and hyperlipidemia. Key words: Stroke;  Brain ischemia;  Renal insufficiency, chronic;  Glomerular filtrationrate;  Risk factors