Мутация гена MTHFR C677T и синдром репродуктивных потерь

Isolated single heterozygous mutation of MTHFR C677T gene has no influence on reproductive outcomes and gestational process. At the same time the homozygous mutation of this gene is the risk factor of pregnancy loss and gestational complications including thrombosis. Mild hyperhomocysteinemia is rather associated with endothelial disfunction than with MTHFR C677T gene mutation.